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Polygenic Risk Scores and Genetically Complex Eye Disease

22 Apr 2024

Abstract excerpt

The success of genome-wide association studies (GWASs) in uncovering genetic variants associated with complex eye diseases has paved the way for the development of risk prediction approaches based on disease genetics. Derived from GWAS data, polygenic risk scores (PRSs) have been emerging as a promising indicator of an individual's genetic liability to disease. In this review, we recap the current progress of PRS...

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PMID: 38648289
DOI: 10.1146/annurev-vision-102122-103958

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