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Evaluation of markers of immunity in different metastatic immune microenvironments suggests more suppression within breast to liver metastases in breast cancer.

Breast cancer research and treatment - 1 Jul 2024

Hsu Robert, Al-Zubeidy Batul, Flores Daniel, Nazarian Ari, Baugh Aaron, Gonzalez Edgar, Castanon Sofi, Xiu Joanne, Kang Irene, Spicer Darcy, Lenz Heinz Josef, Dara Lily, Ademuyiwa Foluso O, Korn W Michael, Irshad Sheeba, Chan Isaac S, Roussos Torres Evanthia T

Abstract excerpt

PURPOSE: Programmed death receptor ligand-1 (PD-L1) expression and tumor mutational burden (TMB) are approved screening biomarkers for immune checkpoint inhibition (ICI) in advanced triple negative breast cancer. We examined these biomarkers along with characterization of the tumor microenvironment (TME) between breast tumors (BrTs), axillary metastases (AxMs), liver metastases (LvMs), non-axillary lymph node...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38643348
DOI: 10.1007/s10549-024-07295-w
PMCID: PMC11182800

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