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Article

Amino acid insertion in Bat MHC-I enhances complex stability and augments peptide presentation

16 May 2024

Abstract excerpt

Abstract Bats serve as reservoirs for numerous zoonotic viruses, yet they typically remain asymptomatic owing to their unique immune system. Of particular significance is the MHC-I in bats, which plays crucial role in anti-viral response and exhibits polymorphic amino acid (AA) insertions. This study demonstrated that both 5AA and 3AA insertions enhance the thermal stability of the bat MHC-I complex and enrich...

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PMID: 38755285
DOI: 10.1038/s42003-024-06292-5

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