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Tissue of origin prediction for cancer of unknown primary using a targeted methylation sequencing panel

9 Feb 2024

Abstract excerpt

RATIONALE: Cancer of unknown primary (CUP) is a group of rare malignancies with poor prognosis and unidentifiable tissue-of-origin. Distinct DNA methylation patterns in different tissues and cancer types enable the identification of the tissue of origin in CUP patients, which could help risk assessment and guide site-directed therapy. METHODS: Using genome-wide DNA methylation profile datasets from The Cancer...

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PMID: 38336771
DOI: 10.1186/s13148-024-01638-6

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