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Article

Age-associated differences in mucosal and systemic host responses to SARS-CoV-2 infection

10 Mar 2025

Abstract excerpt

Age is among the strongest risk factors for severe outcomes from SARS-CoV-2 infection. Here we describe upper respiratory tract (URT) and peripheral blood transcriptomes of 202 participants (age range of 1 week to 83 years), including 137 non-hospitalized individuals with mild SARS-CoV-2 infection and 65 healthy individuals. Among healthy children and adolescents, younger age is associated with higher URT...

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PMID: 40064870
DOI: 10.1038/s41467-025-57655-3

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