Article
BCL2A1 neoepitope-elicited cytotoxic T lymphocytes are a promising individualized immunotherapy of pancreatic cancer.
Journal of leukocyte biology - 2 Sept 2024
Lin Shengzhe, Hong Jingwen, Wu Suxin, Zhu Chenlu, Liu Fang, Lin Wansong, Cai Xinran, Ye Yunbin, Chen Yanling
Abstract excerpt
Conventional treatments have shown a limited efficacy for pancreatic cancer, and immunotherapy is an emerging option for treatment of this highly fatal malignancy. Neoantigen is critical to improving the efficacy of tumor-specific immunotherapy. The cancer and peripheral blood specimens from an HLA-A0201-positive pancreatic cancer patient were subjected to next-generation sequencing, and bioinformatics analyses...
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