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Article

Characteristic fingerprint spectrum of α-synuclein mutants on terahertz time-domain spectroscopy.

Biophysical journal - 21 May 2024

Zhao Xiaofang, Yang Chenlong, Chen Xin, Sun Yu, Liu Weihai, Ge Qinggang, Yang Jun

Abstract excerpt

α-Synuclein, a presynaptic neuronal protein encoded by the SNCA gene, is involved in the pathogenesis of Parkinson's disease. Point mutations and multiplications of α-synuclein (A30P and A53T) are correlated with early-onset Parkinson's disease characterized by rapid progression and poor prognosis. Currently, the clinical identification of SNCA variants, especially disease-related A30P and A53T mutants, remains...

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PMID: 38615192
DOI: 10.1016/j.bpj.2024.04.011
PMCID: PMC11140463

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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