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MGMT Methylation and Differential Survival Impact by Sex in Glioblastoma

31 Mar 2024

Abstract excerpt

Introduction: Sex differences in glioblastoma (GBM) have been observed in incidence, genetic and epigenetic alterations, and immune response. These differences have extended to the methylation of the MGMT promoter, which critically impacts temozolomide resistance. However, the association between sex, MGMT methylation, and survival is poorly understood, which this study sought to evaluate. Methods: A...

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Share to Epigenetics and DNA Methylation
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PMID: 38611052
DOI: 10.3390/cancers16071374

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