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Article

Treatment resistant late-life depression: A narrative review of psychosocial risk factors, non-pharmacological interventions, and the role of clinical phenotyping.

Journal of affective disorders - 1 Jul 2024

Patrick Regan E, Dickinson Rebecca A, Gentry Melanie T, Kim Joseph U, Oberlin Lauren E, Park Soohyun, Principe Jessica L, Teixeira Antonio L, Weisenbach Sara L

Abstract excerpt

BACKGROUND: Treatment resistant depression (TRD) is a subset of major depressive disorder (MDD) in which symptoms do not respond to front line therapies. In older adults, the assessment and treatment of TRD is complicated by psychosocial risk factors unique to this population, as well as a relative paucity of research. METHODS: Narrative review aimed at (1) defining TRLLD for clinical practice and research; (2)...

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PMID: 38593940
DOI: 10.1016/j.jad.2024.04.017

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