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Article

A dynamic regulatory switch for phase separation of FUS protein: Zinc ions and zinc finger domain.

Biochemical and biophysical research communications - 28 May 2024

Chen Yatao, Pei Xiaoying, Chen Long, Chen Liming

Abstract excerpt

Zinc is an important trace element in the human body, and its homeostasis is closely related to amyotrophic lateral sclerosis (ALS). Cytoplasmic FUS proteins from patients with ALS aggregate their important pathologic markers. Liquid-liquid phase separation (LLPS) of FUS can lead to its aggregation. However, whether and how zinc homeostasis affects the aggregation of disease-associated FUS proteins in the...

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Identifiers

PMID: 38593618
DOI: 10.1016/j.bbrc.2024.149862

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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