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Article

Replication stress signaling is a therapeutic target in myelodysplastic syndromes with splicing factor mutations.

Haematologica - 1 Nov 2021

Flach Johanna, Jann Johann-Christoph, Knaflic Antje, Riabov Vladimir, Streuer Alexander, Altrock Eva, Xu Qingyu, Schmitt Nanni, Obländer Julia, Nowak Verena, Danner Justine, Mehralivand Arwin, Hofmann Franziska, Palme Iris, Jawhar Ahmed, Wuchter Patrick, Metzgeroth Georgia, Nolte Florian, Hofmann Wolf-Karsten, Nowak Daniel

Abstract excerpt

Somatic mutations in genes coding for splicing factors, e.g. SF3B1, U2AF1, SRSF2, and others are found in approximately 50% of patients with Myelodysplastic Syndromes (MDS). These mutations have been predicted to frequently occur early in the mutational hierarchy of the disease therefore making them particularly attractive potential therapeutic targets. Recent studies in cell lines engineered to carry splicing...

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Identifiers

PMID: 33054116
DOI: 10.3324/haematol.2020.254193
PMCID: PMC8561278

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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