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SF3B1 mutations induce R-loop accumulation and DNA damage in MDS and leukemia cells with therapeutic implications

19 Feb 2020

Abstract excerpt

The myelodysplastic syndromes (MDS) are common myeloid malignancies characterized by ineffective hematopoiesis and blood cytopenias, with patients showing increasing bone marrow blasts with disease progression [ 1 ]. Mutations in genes involved in pre-mRNA splicing ( SF3B1, SRSF2, U2AF1, and ZRSR2 ) are the most common mutations found in MDS, occurring in over 50% of all cases [ 2 , 3 , 4 ]. There is evidence...

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PMID: 32076118
DOI: 10.1038/s41375-020-0753-9

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