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Article

KLF15 maintains contractile phenotype of vascular smooth muscle cells and prevents thoracic aortic dissection by interacting with MRTFB.

The Journal of biological chemistry - 1 May 2024

Fang Guangming, Tian Yexuan, Huang Shan, Zhang Xiaoping, Liu Yan, Li Yulin, Du Jie, Gao Shijuan

Abstract excerpt

Thoracic aortic dissection (TAD) is a highly dangerous cardiovascular disorder caused by weakening of the aortic wall, resulting in a sudden tear of the internal face. Progressive loss of the contractile apparatus in vascular smooth muscle cells (VSMCs) is a major event in TAD. Exploring the endogenous regulators essential for the contractile phenotype of VSMCs may aid the development of strategies to prevent...

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Identifiers

PMID: 38582447
DOI: 10.1016/j.jbc.2024.107260
PMCID: PMC11061230

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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