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Article

Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer

1 Apr 2024

Abstract excerpt

CD24 is frequently overexpressed in ovarian cancer and promotes immune evasion by interacting with its receptor Siglec10, present on tumor-associated macrophages, providing a "don't eat me" signal that prevents targeting and phagocytosis by macrophages. Factors promoting CD24 expression could represent novel immunotherapeutic targets for ovarian cancer. Here, using a genome-wide CRISPR knockout screen, we...

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Share to Immune Cell Function and Interaction
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PMID: 38573857
DOI: 10.1016/j.celrep.2024.114041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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