Article
High-risk Stage III colon cancer patients identified by a novel five-gene mutational signature are characterized by upregulation of IL-23A and gut bacterial translocation of the tumor microenvironment.
International journal of cancer - 1 Apr 2020
Ge Weiting, Hu Hanguang, Cai Wen, Xu Jinhong, Hu Wangxiong, Weng Xingyue, Qin Xin, Huang Yanqin, Han Weidong, Hu Yeting, Yu Jiekai, Zhang Wufeng, Ye Sisi, Qi Lina, Huang Pingjie, Chen Lirong, Ding Kefeng, Wang Li Dong, Zheng Shu
Abstract excerpt
The heterogeneities of colorectal cancer (CRC) lead to staging inadequately of patients' prognosis. Here, we performed a prognostic analysis based on the tumor mutational profile and explored the characteristics of the high-risk tumors. We sequenced 338 colorectal carcinomas as the training dataset, constructed a novel five-gene (SMAD4, MUC16, COL6A3, FLG and LRP1B) prognostic signature, and validated it in an...
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