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Article

BRAFV600E mutation impinges on gut microbial markers defining novel biomarkers for serrated colorectal cancer effective therapies.

Journal of experimental & clinical cancer research : CR - 14 Dec 2020

Trivieri Nadia, Pracella Riccardo, Cariglia Maria Grazia, Panebianco Concetta, Parrella Paola, Visioli Alberto, Giani Fabrizio, Soriano Amata Amy, Barile Chiara, Canistro Giuseppe, Latiano Tiziana Pia, Dimitri Lucia, Bazzocchi Francesca, Cassano Dario, Vescovi Angelo L, Pazienza Valerio, Binda Elena

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) harboring BRAFV600E mutation exhibits low response to conventional therapy and poorest prognosis. Due to the emerging correlation between gut microbiota and CRC carcinogenesis, we investigated in serrated BRAFV600E cases the existence of a peculiar fecal microbial fingerprint and specific bacterial markers, which might represent a tool for the development of more effective...

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Identifiers

PMID: 33317591
DOI: 10.1186/s13046-020-01801-w
PMCID: PMC7737386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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