Rhenium N-heterocyclic carbene complexes block growth of aggressive cancers by inhibiting FGFR- and SRC-mediated signalling

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Platinum-based anticancer drugs have been at the frontline of cancer therapy for the last 40 years, and are used in more than half of all treatments for different cancer types. However, they are not universally effective, and patients often suffer severe side effects because of their lack of cellular selectivity. There is therefore a compelling need to investiga...

Topics

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• Cell Cycle Proteins
• Dose-Response Relationship, Drug
• Drug Screening Assays, Antitumor
• Histone Deacetylase Inhibitors Research
• Microbial Natural Products and Biosynthesis
• Molecular Structure
• Protein Kinase Inhibitors
• Synthesis and biological activity

Identifiers and source

Literature Corpus work

cb3f55cf-7a1a-51c6-94e7-7357fe060276

DOI

10.21203/rs.3.rs-54828/v2