Article
Identification of a rhodium(iii) complex as a Wee1 inhibitor against TP53-mutated triple-negative breast cancer cells.
Chemical communications (Cambridge, England) - 6 Mar 2018
Yang Guan-Jun, Zhong Hai-Jing, Ko Chung-Nga, Wong Suk-Yu, Vellaisamy Kasipandi, Ye Min, Ma Dik-Lung, Leung Chung-Hang
Abstract excerpt
The rhodium(iii) complex 1 was identified as a potent Wee1 inhibitor in vitro and in cellulo. It decreased Wee1 activity and unscheduled mitotic entry, and induced cell damage and death in TP53-mutated triple-negative breast cancer cells. 1 represents a promising scaffold for further development of more potent metal-based Wee1 antagonists.
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.