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Article

Exploration of new biomarkers for rheumatoid arthritis based on plasma proteomics and transcriptome integrated with genome-wide Mendelian randomization.

Journal of autoimmunity - 1 Aug 2026

Zhang Peng, Liang Youbang, Li Xin, Yang Yihong, Liang Weidong, Yao Xueming, Shen Zhengdong, Wen Yu, Zhan Chenguang, Wu Xiaodong, Ke Peifeng, Mei Liyan, Gao Kaixin, Du Haifang, Chen Xiumin, Zhao Lidan, Wang Maojie, Huang Runyue

Abstract excerpt

OBJECTIVE: Early diagnosis of seronegative rheumatoid arthritis (SNRA) is often challenging due to lack of reliable serological markers. The aim of this study was to explore protein biomarkers of SNRA and identify their potential as therapeutic targets. METHODS: Third-eight seropositive (SPRA) patients and 20 SNRA patients were enrolled in our omics study. Differentially expressed proteins (DEPs) between the two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42456406
DOI: 10.1016/j.jaut.2026.103580

Genes

CAMK2G
NR1H3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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