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Article

Comparisons of screening strategies for identifying Lynch syndrome among patients with MLH1-deficient colorectal cancer.

European journal of human genetics : EJHG - 1 Nov 2020

Xiao Binyi, Luo Jun, Xie E, Kong Lingheng, Tang Jinghua, Liu Dingxin, Mao Linlin, Sui Qiaoqi, Li Weirong, Hong Zhigang, Pan Zhizhong, Jiang Wu, Ding Pei-Rong

Abstract excerpt

BRAF and MLH1 promoter methylation testings have been proven effective prescreens for Lynch Syndrome. We aimed to compare different screening strategies for Lynch Syndrome in patients with MLH1(-) CRC. Patients with MLH1(-) CRC who had been tested for BRAF mutation and germline variants of DNA mismatch repair genes were included. We compared the sensitivities and specificities for identifying Lynch Syndrome and...

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Share to Colorectal Neoplasms, Hereditary Nonpolyposis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to MutL Protein Homolog 1

Share to Proto-Oncogene Proteins B-raf

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Identifiers

PMID: 32661327
DOI: 10.1038/s41431-020-0687-8
PMCID: PMC7575538

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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