Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MLH1 promoter hypermethylation in the analytical algorithm of Lynch syndrome: a cost-effectiveness study.

European journal of human genetics : EJHG - 1 Jul 2012

Gausachs Mireia, Mur Pilar, Corral Julieta, Pineda Marta, González Sara, Benito Llúcia, Menéndez Mireia, Espinàs Josep Alfons, Brunet Joan, Iniesta María Dolores, Gruber Stephen B, Lázaro Conxi, Blanco Ignacio, Capellá Gabriel

Abstract excerpt

The analytical algorithm of Lynch syndrome (LS) is increasingly complex. BRAF V600E mutation and MLH1 promoter hypermethylation have been proposed as a screening tool for the identification of LS. The aim of this study was to assess the clinical usefulness and cost-effectiveness of both somatic alterations to improve the yield of the diagnostic algorithm of LS. A total of 122 colorectal tumors from individuals...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cost-Benefit Analysis

Share to Germ-Line Mutation

Share to Loss of Heterozygosity

Share to Microsatellite Instability

Share to MutL Protein Homolog 1

Share to Proto-Oncogene Proteins B-raf

Source

Open in PubMed Open full text

Identifiers

PMID: 22274583
DOI: 10.1038/ejhg.2011.277
PMCID: PMC3376264

Genes

MLH1
BRAF
MSH2
MSH6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MLH1 promoter hypermethylation in the analytical algorithm of Lynch syndrome: a cost-effectiveness study.PMID 22274583Read ↗

Selection of patients with germline MLH1 mutated Lynch syndrome by determination of MLH1 methylation and BRAF mutation.Semantic proximity Read ↗

Comparisons of screening strategies for identifying Lynch syndrome among patients with MLH1-deficient colorectal cancer.Semantic proximity Read ↗

A prospective, multicenter, population-based study of BRAF mutational analysis for Lynch syndrome screening.Semantic proximity Read ↗

Tumour MLH1 promoter region methylation testing is an effective prescreen for Lynch Syndrome (HNPCC).Semantic proximity Read ↗

Prevalence of somatic mutl homolog 1 promoter hypermethylation in Lynch syndrome colorectal cancerSemantic proximity Read ↗

Testing region selection and prognostic analysis of MLH1 promoter methylation in colorectal cancer in ChinaSemantic proximity Read ↗

Finding the needle in a haystack: identification of cases of Lynch syndrome with MLH1 epimutation.Semantic proximity Read ↗

Germline mutation analysis of MLH1 and MSH2 in Malaysian Lynch syndrome patients.Semantic proximity Read ↗

Comprehensive molecular analysis of mismatch repair gene defects in suspected Lynch syndrome (hereditary nonpolyposis colorectal cancer) cases.Semantic proximity Read ↗

Epidemiological, clinical and molecular characterization of Lynch‐like syndrome: A population‐based studySemantic proximity Read ↗

A tailored approach to BRAF and MLH1 methylation testing in a universal screening program for Lynch syndromeSemantic proximity Read ↗

MLH1 Promotor Hypermethylation in Colorectal and Endometrial Carcinomas from Patients with Lynch SyndromeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.