Genomic and Transcriptomic Characterization of Natural Killer T Cell Lymphoma.

doi:10.1016/j.ccell.2020.02.005

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Article

Genomic and Transcriptomic Characterization of Natural Killer T Cell Lymphoma.

Cancer cell - 16 Mar 2020

Xiong Jie, Cui Bo-Wen, Wang Nan, Dai Yu-Ting, Zhang Hao, Wang Chao-Fu, Zhong Hui-Juan, Cheng Shu, Ou-Yang Bin-Shen, Hu Yu, Zhang Xi, Xu Bin, Qian Wen-Bin, Tao Rong, Yan Feng, Hu Jian-Da, Hou Ming, Ma Xue-Jun, Wang Xin, Liu Yuan-Hua, Zhu Zun-Min, Huang Xiao-Bin, Liu Li, Wu Chong-Yang, Huang Li, Shen Yun-Feng, Huang Rui-Bin, Xu Jing-Yan, Wang Chun, Wu De-Pei, Yu Li, Li Jian-Feng, Xu Peng-Peng, Wang Li, Huang Jin-Yan, Chen Sai-Juan, Zhao Wei-Li

Abstract excerpt

Natural killer/T cell lymphoma (NKTCL) is an aggressive and heterogeneous entity of non-Hodgkin lymphoma, strongly associated with Epstein-Barr virus (EBV) infection. To identify molecular subtypes of NKTCL based on genomic structural alterations and EBV sequences, we performed multi-omics study on 128 biopsy samples of newly diagnosed NKTCL and defined three prominent subtypes, which differ significantly in cell...

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PMID: 32183952
DOI: 10.1016/j.ccell.2020.02.005

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