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Maternal Metformin Treatment during Gestation and Lactation Improves Skeletal Muscle Development in Offspring of Rat Dams Fed High-Fat Diet.

Nutrients - 28 Sept 2021

Cui Jiaqi, Song Lin, Wang Rui, Hu Shuyuan, Yang Zhao, Zhang Zengtie, Sun Bo, Cui Wei

Abstract excerpt

Maternal high-fat (HF) diet is associated with offspring metabolic disorder. This study intended to determine whether maternal metformin (MT) administration during gestation and lactation prevents the effect of maternal HF diet on offspring's skeletal muscle (SM) development and metabolism. Pregnant Sprague-Dawley rats were divided into four groups according to maternal diet {CHOW (11.8% fat) or HF (60% fat)} and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34684418
DOI: 10.3390/nu13103417
PMCID: PMC8538935

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