Article
Comparison of TERT and 5-Hydroxymethylcytocine immunohistochemistry in various thyroid carcinomas.
Annals of diagnostic pathology - 1 Aug 2024
An Hyeong Rok, Kim Won Gu, Lee Yu-Mi, Sung Tae-Yon, Song Dong Eun
Abstract excerpt
Telomerase reverse transcriptase (TERT) promoter mutation is associated with an aggressive clinical course in thyroid carcinomas. Therefore, detection of TERT promoter mutation is essential for proper patient management. 5-Hydroxymethylcytosine (5hmC) is an epigenetic marker involved in the DNA demethylation pathway, and its loss has been observed in various tumors. Loss of 5hmC has also been reported in thyroid...
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