Article
In Japanese patients with papillary thyroid carcinoma, TERT promoter mutation is associated with poor prognosis, in contrast to BRAF V600E mutation.
Virchows Archiv : an international journal of pathology - 1 Dec 2016
Nasirden Almira, Saito Tsuyoshi, Fukumura Yuki, Hara Kieko, Akaike Keisuke, Kurisaki-Arakawa Aiko, Asahina Miki, Yamashita Atsushi, Tomomasa Ran, Hayashi Takuo, Arakawa Atsushi, Yao Takashi
Abstract excerpt
The prognostic value of BRAF V600E and TERT promoter mutation in papillary thyroid carcinoma (PTC) is controversial. We examined alterations in BRAF V600E and TERT promoter by PCR-direct sequencing in PTC of 144 Japanese patients. Alternative lengthening of telomeres was examined as another mechanism of telomere maintenance by immunohistochemical staining for ATRX and DAXX. Of the clinicopathological...
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