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Are changes in olanzapine-induced liver enzyme levels associated with GSTT1, GSTM1, GSTP1, and OGG1 gene polymorphisms?

Arhiv za higijenu rada i toksikologiju - 1 Mar 2024

Elkama Aylin, İlik Nazlıcan, Ak Mehmet, Karahalil Bensu

Abstract excerpt

Olanzapine treatment sometimes produces transient liver biochemistry abnormalities, and such drug-induced liver injuries are mainly monitored by measuring blood levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), whereas alpha-glutathione-S-transferase (α-GST) is not routinely measured in clinics, even though it can serve as an earlier and more specific biomarker of liver damage....

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Identifiers

PMID: 38548381
DOI: 10.2478/aiht-2024-75-3770
PMCID: PMC10978158

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