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Article

Association of 11β-hydroxysteroid dehydrogenase type 1 gene polymorphisms with serum alanine aminotransferase activity.

Diabetes research and clinical practice - 1 Mar 2013

Moon Seong-Su, Lee Young-Sil, Kim Jung-Guk, Lee In-Kyu

Abstract excerpt

AIMS: 11β-Hydroxysteroid dehydrogenase type 1 (HSD11B1), which converts inactive glucocorticoid to active glucocorticoid, plays a critical role in pathogenesis of non-alcoholic fatty liver disease (NAFLD). Serum alanine aminotransferase (ALT), an indicator of hepatocellular injury, has been suggested as a surrogate marker for NAFLD. To date, no study has specifically examined the relationship between HSD11B1 gene...

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PMID: 23375992
DOI: 10.1016/j.diabres.2012.12.020

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