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The Role of Biological Sex in Pre-Clinical (Mouse) mRNA Vaccine Studies

7 Mar 2024

Abstract excerpt

In this study, we consider the influence of biological sex-specific immune responses on the assessment of mRNA vaccines in pre-clinical murine studies. Recognising the established disparities in immune function attributed to genetic and hormonal differences between individuals of different biological sexes, we compared the mRNA expression and immune responses in mice of both biological sexes after intramuscular...

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PMID: 38543916
DOI: 10.3390/vaccines12030282

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