Article
Identification and Validation of a PEX5-Dependent Signature for Prognostic Prediction in Glioma.
Biomolecules - 6 Mar 2024
Qin Xuhui, Wang Bing, Lu Xia, Song Yanyang, Wang Wei
Abstract excerpt
Gliomas, the most prevalent and lethal form of brain cancer, are known to exhibit metabolic alterations that facilitate tumor growth, invasion, and resistance to therapies. Peroxisomes, essential organelles responsible for fatty acid oxidation and reactive oxygen species (ROS) homeostasis, rely on the receptor PEX5 for the import of metabolic enzymes into their matrix. However, the prognostic significance of...
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