FXYD5 promotes the growth of glioblastoma by targeting the PI3K/AKT/ACSL4 signaling axis

Abstract excerpt

<title>Abstract</title> <p> Glioblastoma (GBM) is the most malignant primary brain tumor, with few therapeutic therapy options. Abnormalities of FXYD5 have been reported in multiple malignancies, which proposes FXYD5 as a potential target for precision treatment. Here, we identified that FXYD5 was observably upregulated in GBM and inversely correlated with the prognosis of patients. Functional studies showed tha...

Topics

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• Bioinformatics and Genomic Networks
• Cancer Mechanisms and Therapy
• Ferroptosis and cancer prognosis
• Glioma Diagnosis and Treatment
• Protein Degradation and Inhibitors
• RNA Research and Splicing
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

814af381-3dd6-5dfe-9949-c177d43592ce

DOI

10.21203/rs.3.rs-6967066/v1