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Article

Monolayer culture alters EGFR inhibitor response through abrogation of microRNA-mediated feedback regulation.

Scientific reports - 27 Mar 2024

Florio Angela, Johnson Sarah, Salvatori Rebecca, Vasmatzis George

Abstract excerpt

Ex vivo drug screening is a potentially powerful tool for the future of cancer care, but the accuracy of results is contingent on the culture model. Both monolayer (2D) and spheroid (3D) culture systems offer advantages, but given the differences in mechanical environment, we hypothesized that that the suitability of one system over another would be critical for screening drugs with mechanical targets in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38538642
DOI: 10.1038/s41598-024-56920-7
PMCID: PMC10973516

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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