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Article

A Combined 3D Tissue Engineered In Vitro/In Silico Lung Tumor Model for Predicting Drug Effectiveness in Specific Mutational Backgrounds.

Journal of visualized experiments : JoVE - 6 Apr 2016

Göttlich Claudia, Müller Lena C, Kunz Meik, Schmitt Franziska, Walles Heike, Walles Thorsten, Dandekar Thomas, Dandekar Gudrun, Nietzer Sarah L

Abstract excerpt

In the present study, we combined an in vitro 3D lung tumor model with an in silico model to optimize predictions of drug response based on a specific mutational background. The model is generated on a decellularized porcine scaffold that reproduces tissue-specific characteristics regarding extracellular matrix composition and architecture including the basement membrane. We standardized a protocol that allows...

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Source

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Identifiers

PMID: 27077967
DOI: 10.3791/53885
PMCID: PMC4841364

Genes

EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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