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Application of Mendelian randomization analysis to explore causal associations of aspirin use with bone mineral density and risk of fracture.

Hereditas - 7 Jan 2025

Liu Qi-Pei

Abstract excerpt

OBJECTIVE: Previous observational studies on the association between aspirin use, bone mineral density (BMD), and fracture risk have yielded controversial results. This study explored the causal relationship between aspirin use, BMD, and fracture risk using Mendelian randomization (MR). METHODS: Summary data for aspirin use and BMD of five different body parts (femoral neck, lumbar spine, forearm, heel, and ultra...

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PMID: 39773558
DOI: 10.1186/s41065-024-00359-3

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