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Genetic underpinnnings of type 2 diabetes.

Advances in genetics - 1 Jan 2025

Shah Aditya, Bush Clancy O, Perry Rachel J

Abstract excerpt

Genetics is a significant risk factor for developing type 2 diabetes, with a family history conferring a 1.5-3-fold increased risk. Intriguingly, this heritable risk is higher when the affected parent is the mother, suggesting a potential role of mitochondrial genetics -maternally inherited DNA - in diabetes pathogenesis, a hypothesis this chapter will explore. While obesity mediates some of the genetic risk of...

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PMID: 40409800
DOI: 10.1016/bs.adgen.2024.12.001

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