Article
A 21-bp deletion in the complement regulator CD55 promotor region is associated with multifocal motor neuropathy and its disease course.
Journal of the peripheral nervous system : JPNS - 1 Jun 2024
Bos Jeroen W, Groen Ewout J N, Otten Henny G, Budding Kevin, van Eijk Ruben P A, Curial Chantall, Kardol-Hoefnagel Tineke, Goedee H Stephan, van den Berg Leonard H, van der Pol W Ludo
Abstract excerpt
BACKGROUND AND AIMS: To further substantiate the role of antibody-mediated complement activation in multifocal motor neuropathy (MMN) immunopathology, we investigated the distribution of promotor polymorphisms of genes encoding the membrane-bound complement regulators CD46, CD55, and CD59 in patients with MMN and controls, and evaluated their association with disease course. METHODS: We used Sanger sequencing to...
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