Article
CYBA allelic variants are associated with severity and recovery in Guillain-Barré syndrome.
Journal of the peripheral nervous system : JPNS - 1 Sept 2023
Törnell Andreas, Lagerström Nina, Mossberg Natalia, Kiffin Roberta, Farman Helen, Lycke Jan, Andersen Oluf, Axelsson Markus, Hellstrand Kristoffer, Martner Anna
Abstract excerpt
BACKGROUND AND AIMS: Guillain-Barré syndrome (GBS) is a rare, acute neuropathy characterized by ascending muscle weakness. Age, axonal GBS variants, and antecedent Campylobacter jejuni infection are associated with severe GBS, but the detailed mechanisms of nerve damage are only partly explored. Pro-inflammatory myeloid cells express NADPH oxidases (NOX) that generate tissue-toxic reactive oxygen species (ROS)...
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