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Ropivacaine as a novel AKT1 specific inhibitor regulates the stemness of breast cancer

25 Mar 2024

Abstract excerpt

BACKGROUND: Ropivacaine, a local anesthetic, exhibits anti-tumor effects in various cancer types. However, its specific functions and the molecular mechanisms involved in breast cancer cell stemness remain elusive. METHODS: The effects of ropivacaine on breast cancer stemness were investigated by in vitro and in vivo assays (i.e., FACs, MTT assay, mammosphere formation assay, transwell assays, western blot, and...

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PMID: 38523299
DOI: 10.1186/s13046-024-03016-9

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