Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Napabucasin, a novel STAT3 inhibitor suppresses proliferation, invasion and stemness of glioblastoma cells

5 Jul 2019

Abstract excerpt

BACKGROUND: Glioblastoma (GBM) cells with stem cell-like properties are called glioma stem cells (GSCs). GSCs display highly treatment resistance and are responsible for tumor recurrence. Napabucasin (BBI608), a novel small molecule inhibitor of STAT3, has been identified to eliminate stemness-like tumor cells in some cancers. However, the influence of Napabucasin on GBM cells, especially on GSCs, is currently...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bioactive Compounds and Antitumor Agents
Share to Cancer, Hypoxia, and Metabolism
Share to Cytokine Signaling Pathways and Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31277685
DOI: 10.1186/s13046-019-1289-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Napabucasin, a novel STAT3 inhibitor suppresses proliferation, invasion and stemness of glioblastoma cellsPMID 31277685Read ↗

Apigenin Inhibits Cancer Stem Cell-Like Phenotypes in Human Glioblastoma Cells via Suppression of c-Met Signaling.Semantic proximity Read ↗

Crebanine, an aporphine alkaloid, induces cancer cell apoptosis through PI3K-Akt pathway in glioblastoma multiformeSemantic proximity Read ↗

Lnc GNG12-AS1 knockdown suppresses glioma progression through the AKT/GSK-3β/β-catenin pathwaySemantic proximity Read ↗

Morusin inhibits glioblastoma stem cell growth in vitro and in vivo through stemness attenuation, adipocyte transdifferentiation, and apoptosis inductionSemantic proximity Read ↗

Sema3C Promotes the Survival and Tumorigenicity of Glioma Stem Cells through Rac1 ActivationSemantic proximity Read ↗

GCSF, A Diagnostic Marker and Potential Drug Target Candidate in GlioblastomaSemantic proximity Read ↗

Potential diagnostic and drug target markers in glioblastomaSemantic proximity Read ↗

STAT3 is essential for the maintenance of neurosphere‐initiating tumor cells in patients with glioblastomas: A potential for targeted therapy?Semantic proximity Read ↗

Alpha 1-antichymotrypsin contributes to stem cell characteristics and enhances tumorigenicity of glioblastomaSemantic proximity Read ↗

Topoisomerase I Inhibitors, Shikonin and Topotecan, Inhibit Growth and Induce Apoptosis of Glioma Cells and Glioma Stem CellsSemantic proximity Read ↗

STAT3 as a Therapeutic Target for GlioblastomaSemantic proximity Read ↗

Sortilin promotes glioblastoma invasion and mesenchymal transition through GSK-3β/β-catenin/twist pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.