Genetically predicted sex hormone binding globulin and ischemic heart disease in men and women: a univariable and multivariable Mendelian randomization study.

doi:10.1038/s41598-021-02510-w

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Article

Genetically predicted sex hormone binding globulin and ischemic heart disease in men and women: a univariable and multivariable Mendelian randomization study.

Scientific reports - 30 Nov 2021

Zhao Jie V, Schooling C Mary

Abstract excerpt

Men are more vulnerable to ischemic heart disease (IHD) than women, possibly due to testosterone. Correspondingly, sex hormone binding globulin (SHBG) which lowers circulating testosterone might protect men against IHD. SHBG may also affect IHD independent of testosterone, which has not previously been examined. To assess the sex-specific role of SHBG in IHD, in univariable Mendelian randomization (MR), we used...

Topics

Adult
Aged
Biological Specimen Banks
Disease Susceptibility
Endocrinology
Female
Genetic Variation
Humans
Japan
Male
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Multivariate Analysis

Myocardial Ischemia

Odds Ratio

Polymorphism, Single Nucleotide

Risk Factors

Sex Hormone-Binding Globulin

Source

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Identifiers

PMID: 34848757
DOI: 10.1038/s41598-021-02510-w
PMCID: PMC8632960

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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