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Growth and differentiation factor-15: A link between inflammaging and cardiovascular disease

24 Mar 2024

Abstract excerpt

Age-related disorders are closely linked to the accumulation of senescent cells. The senescence-associated secretory phenotype (SASP) sustains and progresses chronic inflammation, which is involved in cellular and tissue dysfunction. SASP-related growth and differentiation factor-15 (GDF-15) is an immunoregulatory cytokine that is coupled to aging and thus may have a regulatory role in the development and...

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PMID: 38522236
DOI: 10.1016/j.biopha.2024.116475

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