Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Triple action Pt( iv ) derivatives of cisplatin: a new class of potent anticancer agents that overcome resistance

1 Jan 2018

Abstract excerpt

], where COXi = aspirin or ibuprofen, PDKi = dichloroacetate and HDACi = valproate or phenylbutyrate, were significantly more cytotoxic than cisplatin against all cell lines of an in-house panel of human cancer cells. They were particularly effective against thyroid and pancreatic cancer cells in monolayer cytotoxicity tests. Remarkably, in 3D spheroid cancer cell cultures, some triple action compounds showed an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Click Chemistry and Applications
Share to Ferrocene Chemistry and Applications
Share to Metal complexes synthesis and properties

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29780561
DOI: 10.1039/c8sc00428e

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Triple action Pt( iv ) derivatives of cisplatin: a new class of potent anticancer agents that overcome resistancePMID 29780561Read ↗

The Drug-Resistance Mechanisms of Five Platinum-Based Antitumor AgentsSemantic proximity Read ↗

DNA-Unresponsive Platinum(II) Complex Induces ERS-Mediated Mitophagy in Cancer CellsSemantic proximity Read ↗

Multiaction Platinum(IV) Prodrug Containing Thymidylate Synthase Inhibitor and Metabolic Modifier against Triple-Negative Breast CancerSemantic proximity Read ↗

Platinum iodido drugs show potential anti-tumor activity, affecting cancer cell metabolism and inducing ROS and senescence in gastrointestinal cancer cellsSemantic proximity Read ↗

A Platinum(IV) Anticancer Prodrug Targeting Nucleotide Excision Repair To Overcome Cisplatin ResistanceSemantic proximity Read ↗

A Platinum(IV) Anticancer Prodrug Targeting Nucleotide Excision Repair To Overcome Cisplatin ResistanceSemantic proximity Read ↗

Cisplatin and beyond: molecular mechanisms of action and drug resistance development in cancer chemotherapySemantic proximity Read ↗

Fresh Platinum Complexes with Promising Antitumor ActivitySemantic proximity Read ↗

Metal-based anticancer drugs: From a past anchored in platinum chemistry to a post-genomic future of diverse chemistry and biologySemantic proximity Read ↗

Cisplatin and platinum drugs at the molecular level. (Review).Semantic proximity Read ↗

Mitaplatin Increases Sensitivity of Tumor Cells to Cisplatin by Inducing Mitochondrial DysfunctionSemantic proximity Read ↗

Mechanistic added value of a trans-Sulfonamide-Platinum-Complex in human melanoma cell lines and synergism with cis-Platin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.