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Article

Aminoglycoside resistance of Pseudomonas aeruginosa in cystic fibrosis results from convergent evolution in the mexZ gene.

Thorax - 1 Jan 2017

Prickett Michelle H, Hauser Alan R, McColley Susanna A, Cullina Joanne, Potter Eileen, Powers Cathy, Jain Manu

Abstract excerpt

RATIONALE: Aminoglycoside (AG) resistance of Pseudomonas aeruginosa in cystic fibrosis (CF) is associated with poorer clinical outcomes and is usually due to overexpression of the efflux pump MexXY. MexXY is regulated by mexZ, one of the most commonly mutated genes in CF P. aeruginosa isolates. Little is known about the evolutionary relationship between AG resistance, MexXY expression and mexZ mutations....

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Identifiers

PMID: 27325751
DOI: 10.1136/thoraxjnl-2015-208027
PMCID: PMC5497499

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Aminoglycoside resistance of Pseudomonas aeruginosa in cystic fibrosis results from convergent evolution in the mexZ gene.PMID 27325751Read ↗

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