Article
Identification of the cellular mechanisms that modulate trafficking of frizzled family receptor 4 (FZD4) missense mutants associated with familial exudative vitreoretinopathy.
Investigative ophthalmology & visual science - 17 Apr 2014
Milhem Reham M, Ben-Salem Salma, Al-Gazali Lihadh, Ali Bassam R
Abstract excerpt
PURPOSE: Fifteen missense mutations in the frizzled family receptor 4 (FZD4) reported to cause familial exudative vitreoretinopathy (FEVR) were evaluated to establish the pathological cellular mechanism of disease and to explore novel therapeutic strategies. METHODS: The mutations were generated...
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