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Article

Role of interleukin 6 signaling pathway in the anti-inflammatory effects of statins on coronary artery disease: Evidence from Mendelian randomization analysis.

International journal of cardiology - 1 Jul 2024

Yazdanpanah Mojgan, Yazdanpanah Nahid, Chardoli Mojtaba, Dehghan Abbas

Abstract excerpt

BACKGROUND: Statins are currently widely used in the prevention of coronary artery disease (CAD) primarily for lipid-lowering with a potential anti-inflammatory effect. However, it is not clear if their potential anti-inflammatory effects are mediated through the interleukin 6 (IL-6) signaling pathway. METHODS: Using the Mendelian randomization (MR) approach followed by multivariable MR analyses, we examined the...

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Anti-Inflammatory Agents
Coronary Artery Disease
APOB gene
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Interleukin-6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Polymorphism, Single Nucleotide

Signal Transduction

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Identifiers

PMID: 38513732
DOI: 10.1016/j.ijcard.2024.131964

Genes

CAD
APOB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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