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Article

Dendritic cell phenotype and function in a 3D co-culture model of patient-derived metastatic colorectal cancer organoids.

Frontiers in immunology - 1 Jan 2023

Subtil Beatriz, Iyer Kirti K, Poel Dennis, Bakkerus Lotte, Gorris Mark A J, Escalona Jorge Cuenca, van den Dries Koen, Cambi Alessandra, Verheul Henk M W, de Vries I Jolanda M, Tauriello Daniele V F

Abstract excerpt

Colorectal cancer (CRC) remains one of the most aggressive and lethal cancers, with metastasis accounting for most deaths. As such, there is an unmet need for improved therapies for metastatic CRC (mCRC). Currently, the research focus is shifting towards the reciprocal interactions within the tumor microenvironment (TME), which prevent tumor clearance by the immune system. Dendritic cells (DCs) play a key role in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36761758
DOI: 10.3389/fimmu.2023.1105244
PMCID: PMC9905679

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