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Immunopeptidomics-based identification of naturally presented non-canonical circRNA-derived peptides

15 Mar 2024

Abstract excerpt

Circular RNAs (circRNAs) are covalently closed non-coding RNAs lacking the 5' cap and the poly-A tail. Nevertheless, it has been demonstrated that certain circRNAs can undergo active translation. Therefore, aberrantly expressed circRNAs in human cancers could be an unexplored source of tumor-specific antigens, potentially mediating anti-tumor T cell responses. This study presents an immunopeptidomics workflow...

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PMID: 38490980
DOI: 10.1038/s41467-024-46408-3

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