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Article

An X Chromosome Transcriptome Wide Association Study Implicates ARMCX6 in Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2024

Zhang Xueyi, Gomez Lissette, Below Jennifer E, Naj Adam C, Martin Eden R, Kunkle Brian W, Bush William S

Abstract excerpt

Background: The X chromosome is often omitted in disease association studies despite containing thousands of genes that may provide insight into well-known sex differences in the risk of Alzheimer's disease (AD). Objective: To model the expression of X chromosome genes and evaluate their impact on AD risk in a sex-stratified manner. Methods: Using elastic net, we evaluated multiple modeling strategies in a set of...

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Identifiers

PMID: 38489177
DOI: 10.3233/JAD-231075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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