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OrgaSegment: deep-learning based organoid segmentation to quantify CFTR dependent fluid secretion

13 Mar 2024

Abstract excerpt

Epithelial ion and fluid transport studies in patient-derived organoids (PDOs) are increasingly being used for preclinical studies, drug development and precision medicine applications. Epithelial fluid transport properties in PDOs can be measured through visual changes in organoid (lumen) size. Such organoid phenotypes have been highly instrumental for the studying of diseases, including cystic fibrosis (CF),...

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PMID: 38480810
DOI: 10.1038/s42003-024-05966-4

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