Article
Rectal organoid morphology analysis (ROMA) as a promising diagnostic tool in cystic fibrosis.
Thorax - 1 Nov 2021
Cuyx Senne, Ramalho Anabela Santo, Corthout Nikky, Fieuws Steffen, Fürstová Eva, Arnauts Kaline, Ferrante Marc, Verfaillie Catherine, Munck Sebastian, Boon Mieke, Proesmans Marijke, Dupont Lieven, De Boeck Kris, Vermeulen François
Abstract excerpt
Diagnosing cystic fibrosis (CF) when sweat chloride is not in the CF range and less than 2 disease-causing CFTR mutations are found requires physiological CFTR assays, which are not always feasible or available. We developed a new physiological CFTR assay based on the morphological differences between rectal organoids from subjects with and without CF. In organoids from 167 subjects with and 22 without CF, two...
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