Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Studying the Effect of MBNL1 and MBNL2 Loss in Skeletal Muscle Regeneration

26 Feb 2024

Abstract excerpt

Loss of function of members of the muscleblind-like (MBNL) family of RNA binding proteins has been shown to play a key role in the spliceopathy of RNA toxicity in myotonic dystrophy type 1 (DM1), the most common muscular dystrophy affecting adults and children. MBNL1 and MBNL2 are the most abundantly expressed members in skeletal muscle. A key aspect of DM1 is poor muscle regeneration and repair, leading to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathy and Myosin Studies
Share to Genetic Neurodegenerative Diseases
Share to Muscle Physiology and Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38473933
DOI: 10.3390/ijms25052687

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Studying the Effect of MBNL1 and MBNL2 Loss in Skeletal Muscle RegenerationPMID 38473933Read ↗

Modeling muscle regeneration in RNA toxicity miceSemantic proximity Read ↗

RNA-binding Protein Muscleblind-like 3 (MBNL3) Disrupts Myocyte Enhancer Factor 2 (Mef2) β-Exon SplicingSemantic proximity Read ↗

Compound loss of muscleblind‐like function in myotonic dystrophySemantic proximity Read ↗

Myotonic dystrophy: is a narrow focus obscuring the rest of the field?Semantic proximity Read ↗

Muscleblind-Like 1 and Muscleblind-Like 3 Depletion Synergistically Enhances Myotonia by Altering Clc-1 RNA TranslationSemantic proximity Read ↗

Autoregulated Splicing of muscleblind-like 1 (MBNL1) Pre-mRNASemantic proximity Read ↗

(CTG)n repeat-mediated dysregulation of MBNL1 and MBNL2 expression during myogenesis in DM1 occurs already at the myoblast stageSemantic proximity Read ↗

Myotonic Dystrophy and Developmental Regulation of RNA Processing.Semantic proximity Read ↗

Zebrafish <i>mbnl</i> mutants model physical and molecular phenotypes of myotonic dystrophySemantic proximity Read ↗

Zebrafish mbnl mutants model physical and molecular phenotypes of myotonic dystrophy.Semantic proximity Read ↗

MBNL‐dependent impaired development within the neuromuscular system in myotonic dystrophy type 1Semantic proximity Read ↗

Abnormalities in Skeletal Muscle Myogenesis, Growth, and Regeneration in Myotonic DystrophySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.